HMS Penelope was a Nike-class battlecruiser of the Royal Manticoran Navy.
Completed in 1921 PD and commanded by Captain (SG) Jerome Conner, she was assigned to Battlecruiser Squadron 106 and deployed to the Talbott Quadrant. She served as the flagship of her division within the squadron. Penelope was stationed in the Tillerman System as a picket. (SI2)